Alright, I'm wondering if the following can be used to make actually useful characters; just to make it difficult, you have to supply how they have such a massive handicap and have to find a way to make this handicap useful (i.e. don't mitigate the problem, use the problem to be awesome.):
A character with a base speed of 5 or less.
A character with at least 1 save that's really, really awful (as in, autofails any saving throw with it)
A character with an armor class of 1
A character with 1 HP... maximum
They don't all have to be on the same character.