I haven't worked out the high level stuff, but this is what I was going to start with in a new game:
Human Cleric
Sacred Flames, Righteous Brand, Lance of Faith (at will)
Wrathful Thunder (per encounter)
Guardian of Faith (per day)
Action Surge, Ritual Caster, TBD... (feats)
Religion, Heal, Arcana, Insight (skills)
Basically, a melee Cleric w/ some summoning and rituals. I know I'll take CLW at 2nd, but other than that I don't have much of a clue (mainly b/c I haven't had time to look at everything).
I don't think the Human's bonus at-will power is worth it... but the defensive bonuses and extra skill is. Not sure about the feat... Action Surge seems pretty awesome, though, which is a great reason to play a Human; I might add Power Attack in, even though its much weaker in 4th ed.