We've been having a ton of fun with Alpha Omega. Its not perfect, but its got a lot of really cool aspects.
Upsides
-The way you determine what dice you roll is pretty cool. Kind of hard to explain, but its very neat.
-Characters have a very gradual power increase curve. It does a "buy things with xp" system like WhiteWolf games, so you can give more xp if you want larger jumps or you can take it slower.
-The magic system is very open. This has benefits and drawbacks obviously, but if you police it a bit it can work well.
-Game reacts very well to just playing under subsets of rules. Not including something usually doesn't auto-break the game.
Downsides
-Very fiddly and math centered. There are 7 "core qualities", then several "Secondary Qualities" that are averages of two core scores, then there are even some "Tertiary Qualities" that are averages of secondaries!
-Charts upon charts upon charts.
-The physical books are done in landscape mode. Sometimes this is cool, usually its just annoying.
-I am not a huge fan of their default setting, but its not the worst I have seen.