About 4th edition, I think we should wait until it is released. We don't have material to do anything yet, i Think.
In my experience, reasonable Min/Maxing requires a game system with some intrinsic characteristics that not every system has. Coherent and descriptive rules are one of them. Min/maxing is a thought exercise, an effort made by players to be prepared for every obstacle and be able to overcome them with minimal effort and the highest possible success rate. If the rules aren't solid enough, the result of an action depends primarily on the game director, and most of the possibilities the player could have thought of can be unvalidated. The example is obvious: WoD. I have seen many people trying to max/max (maximize advantages even if that mean maximizing disadvantages, for an extremely focused character) in V:tM, and a simple first level discipline, presence, made them useless in many games, while in other campaigns they were almost unbeatable.
That said, I'm starting to want to try some min/maxing with my old rolemaster books...
