Thank you for the advice. All affects should appear external; ie, potentially caused by forces other than insanity, thus, leaving it ambiguous. At the end of the campaign, I want the question to be if it was actually magic driving them insane, or if there was a hostile force messing with them. Furthermore, like I said, I'll later have them "curing" the effect, though I intend to leave it ambiguous as to whether they were affected at all. I guess the question can be modified to "What would a powerful wizard do to subtly screw with a party in minor and indirect ways?" (Ventriloquism to make NPC's hear the wrong thing, silent images to have people crash into doors, illusions or charms to have random NPC's in taverns behave strangely).
Edit: Also, our group has a history of players going insane for various reasons, characters being mutilated/transformed/etcetera...the most drastic of which was a wizard being turned into a yak-folk --- and this was not my DMing. I think our interpretation is that in the violent and chaotic worlds we play, bad things can happen.